It has been rumored for a while now that Peter Parker will slowly devolve into Man-Spider throughout Brand New Day, and in the trailer, there's plenty of evidence to support that idea.
We see him emerge from a cocoon while his eyes are engulfed in black and red; he starts to shoot organic webs in place of his webshooters; still in the costume, he undergoes a full body scan; Bruce Banner warns him about the dangers of mutation; and Keith David narrates about the lifecycles of a spider, and how it amounts to a kind of "rebirth" — some fans even think the extra Man-Spider arms were cut out of certain scenes in the trailer to mask the truth.
Interestingly, the What if? series wasn't allowed to use Man-Spider.
Destin Daniel Cretton will be taking a big swing if he really is adapting this arc, as it's one of the most unsettling body horror stories in the character's extensive 60-year history. However, technically speaking, The Amazing Spider-Man beat the MCU to the punch 14 years ago.
As pointed out by X user @GothicHeros, the tie-in Amazing Spider-Man game from 2012 featured a skin called "Cross-Species Spider-Man,"...
